How long does tirzepatide titration take?

On the Zepbound label, treatment starts at 2.5 mg once weekly for four weeks, then 5 mg, with increases in 2.5 mg steps after at least four weeks on each dose, up to a maximum of 15 mg. Reaching 15 mg therefore takes at least 20 weeks. Maintenance doses on the label are 5, 10 or 15 mg; your clinician sets the pace, and many people stay longer on a dose if side effects are troublesome.